Carbon Utilization Redesign for Biomanufacturing (CURB)

The Carbon Utilization Redesign for Biomanufacturing (CURB) Engineering Research Center (ERC) is an NSF-funded center started in 2024. The goal of CURB is to use CO₂ as a feedstock by utilizing bio-manufacturing through various pathways, including both cell-based and cell-free conversions. Within the CURB center, the Zhou group is focused on developing advanced MOFs for CO₂ capture and electrochemical reduction (CO₂RR), as well as enabling substrate channeling through enzyme immobilization. Building on previous enzyme immobilization research, including PCN-333-Al and PCN-888, the MOFs provide a protective layer to the enzymes, allowing for improved recyclability and efficiency for C₂₊ product formation. Additionally, the Zhou group is exploring catalytically active direct air capture materials for the capture and conversion of CO₂ to C₂₊ products through electro- and photochemical methods by precisely designing active linkers and regulating metal-metal distances within the framework. By providing synergistic materials for both cell-based and cell-free systems, the Zhou group closely works with CURB researchers to achieve a common goal of CO₂ utilization.